High Incidence of Metabolically Active Brown Adipose Tissue in Healthy Adult Humans Effects of Cold Exposure and Adiposity

被引：1466

作者：

Saito, Masayuki ^{[1
]}

Okamatsu-Ogura, Yuko ^{[2
]}

Matsushita, Mami ^{[1
]}

Watanabe, Kumiko ^{[1
]}

Yoneshiro, Takeshi ^{[1
]}

Nio-Kobayashi, Junko ^{[2
]}

Iwanaga, Toshihiko ^{[3
]}

Miyagawa, Masao ^{[4
]}

Kameya, Toshimitsu ^{[5
]}

Nakada, Kunihiro ^{[5
]}

Kawai, Yuko ^{[5
]}

Tsujisaki, Masayuki ^{[5
]}

机构：

[1] Tenshi Coll, Sch Nursing & Nutr, Dept Nutr, Sapporo, Hokkaido, Japan

[2] Hokkaido Univ, Grad Sch Vet Med, Dept Biomed Sci, Sapporo, Hokkaido, Japan

[3] Hokkaido Univ, Grad Sch Med, Sapporo, Hokkaido, Japan

[4] Ehime Hosp, PET Ctr, Matsuyama, Ehime, Japan

[5] LSI Sapporo Clin, Sapporo, Hokkaido, Japan

来源：

DIABETES | 2009年 / 58卷 / 07期

关键词：

DIET-INDUCED THERMOGENESIS; UNCOUPLING PROTEIN-1; GLUCOSE-UTILIZATION; F-18-FDG PET/CT; WHITE FAT; USA-FAT; OBESITY; MICE; UCP1; TEMPERATURE;

D O I：

10.2337/db09-0530

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

OBJECTIVE-The significant roles of brown adipose tissue (BAT) in the regulation of energy expenditure and adiposity are established in small rodents but have been controversial in humans. The objective is to examine the prevalence of metabolically active BAT in healthy adult humans and to clarify the effects of cold exposure and adiposity. RESEARCH DESIGN AND METHODS-In vivo 2-[(18)F]fluoro-2-deoxyglucose (FDG) uptake into adipose tissue was measured in 56 healthy volunteers (31 male and 25 female subjects) aged 23-65 years by positron emission tomography (PET) combined with X-ray computed tomography (CT). RESULTS-When exposed to cold (19 C) for 2 h, 17 of 32 younger subjects (aged 23-35 years) and 2 of 24 elderly subjects (aged 38-65 years) showed a substantial FDG uptake into adipose tissue of the supraclavicular and paraspinal regions, whereas they showed no detectable uptake when kept warm (27 C). Histological examinations confirmed the presence of brown adipocytes in these regions. The cold-activated FDG uptake was increased in winter compared with summer (P < 0.001) and was inversely related to BMI (P < 0.001) and total (P < 0.01) and visceral (P < 0.001) fat areas estimated from CT image at the umbilical level. CONCLUSIONS-Our findings, being against the conventional view, indicate the high incidence of metabolically active BAT in adult humans and suggest a role in the control of body temperature and adiposity. Diabetes 58:1526-1531, 2009

引用

页码：1526 / 1531

页数：6

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