The use of some ingredients for microemulsion preparation containing retinol and its esters

A study of microemulsions with retinol and its esters. Physical properties of w/o and o/w microemulsions containing Tween 60, Tween 80, Epicurone 135 (soy bean lecithin) as surfactants, n-butanol, triacetin. propylene glycol as cosurfactants were examined. The drug-containing systems were characterised in regard to their ophthalmic parameters. Physiologically well-tolerated and physically stable multiple-components were developed. The concentrations of surfactants and cosurfactants which are necessary to form stable systems were evaluated. The values of the following parameters - refractive index, viscosity, pH value, osmotic tension, obtained in the study, proved suitable for the purpose and the preparations were physiologically tolerated, the use of microemulsions as potential drug delivery systems for ocular administration has been discussed. The influence of retinol and its esters on the physical parameters the preparation was investigated. Microemulsion stored at 20 degrees C up to 6 months showed no significant physical changes. (C) 2000 Published by Elsevier Science B.V. All rights reserved.