Aminoalkoxybiphenylnitriles as histamine-3 receptor ligands

被引:42
作者
Faghih, R [1 ]
Dwight, W [1 ]
Vasudevan, A [1 ]
Dinges, J [1 ]
Conner, SE [1 ]
Esbenshade, TA [1 ]
Bennani, YL [1 ]
Hancock, AA [1 ]
机构
[1] Abbott Labs, Global Pharmaceut Res & Dev, Neurosci Res, Abbott Pk, IL 60064 USA
关键词
D O I
10.1016/S0960-894X(02)00648-0
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
Biaryl nitrile amines were prepared and found to have high affinity and selectivity for human and rat histamine H-3 receptors. (C) 2002 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码:3077 / 3079
页数:3
相关论文
共 26 条
[1]   Design, synthesis, and structure-activity relationships of acetylene-based histamine H3 receptor antagonists [J].
Ali, SM ;
Tedford, CE ;
Gregory, R ;
Handley, MK ;
Yates, SL ;
Hirth, WW ;
Phillips, JG .
JOURNAL OF MEDICINAL CHEMISTRY, 1999, 42 (05) :903-909
[2]   HIGHLY POTENT AND SELECTIVE LIGANDS FOR HISTAMINE RECEPTORS-H-3 [J].
ARRANG, JM ;
GARBARG, M ;
LANCELOT, JC ;
LECOMTE, JM ;
POLLARD, H ;
ROBBA, M ;
SCHUNACK, W ;
SCHWARTZ, JC .
NATURE, 1987, 327 (6118) :117-123
[3]   RECEPTORS MEDIATING SOME ACTIONS OF HISTAMINE [J].
ASH, ASF ;
SCHILD, HO .
BRITISH JOURNAL OF PHARMACOLOGY AND CHEMOTHERAPY, 1966, 27 (02) :427-&
[4]   DEFINITION AND ANTAGONISM OF HISTAMINE H2-RECEPTORS [J].
BLACK, JW ;
PARSONS, EM ;
DURANT, CJ ;
DUNCAN, WAM ;
GANELLIN, CR .
NATURE, 1972, 236 (5347) :385-&
[5]  
DENNY LI, 2001, EUR J PHARMACOL, V433, P141
[6]  
Drutel G, 2001, MOL PHARMACOL, V59, P1
[7]  
FAGHIH R, IN PRESS BIOORG MED
[8]   Effects of histamine H3 receptor ligands GT-2331 and ciproxifan in a repeated acquisition avoidance response in the spontaneously hypertensive rat pup [J].
Fox, GB ;
Pan, JB ;
Esbenshade, TA ;
Bennani, YL ;
Black, LA ;
Faghih, R ;
Hancock, AA ;
Decker, MW .
BEHAVIOURAL BRAIN RESEARCH, 2002, 131 (1-2) :151-161
[9]  
GARBARG M, 1992, J PHARMACOL EXP THER, V263, P304
[10]  
HALPERN MT, 1999, CURR OPIN CENT PERIP, V1, P524