Microenvironmental regulation of metastasis

被引:2774
作者
Joyce, Johanna A. [1 ]
Pollard, Jeffrey W. [2 ]
机构
[1] Mem Sloan Kettering Canc Ctr, Canc Biol & Genet Program, New York, NY 10021 USA
[2] Albert Einstein Coll Med, Dept Dev & Mol Biol, Dept Obstet & Gynecol & Womens Hlth, Ctr Study Reprod Biol & Womens Hlth, New York, NY USA
关键词
TUMOR-ASSOCIATED MACROPHAGES; ENDOTHELIAL PROGENITOR CELLS; MESENCHYMAL STEM-CELLS; NATURAL-KILLER-CELLS; BREAST-CANCER; MYELOID CELLS; SUPPRESSOR-CELLS; GROWTH-FACTOR; ANGIOGENIC SWITCH; MATRIX METALLOPROTEINASES;
D O I
10.1038/nrc2618
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Metastasis is a multistage process that requires cancer cells to escape from the primary tumour, survive in the circulation, seed at distant sites and grow. Each of these processes involves rate-limiting steps that are influenced by non-malignant cells of the tumour microenvironment. Many of these cells are derived from the bone marrow, particularly the myeloid lineage, and are recruited by cancer cells to enhance their survival, growth, invasion and dissemination. This Review describes experimental data demonstrating the role of the microenvironment in metastasis, identifies areas for future research and suggests possible new therapeutic avenues.
引用
收藏
页码:239 / 252
页数:14
相关论文
共 193 条
[1]  
ADAMSON IYR, 1987, LAB INVEST, V57, P71
[2]   Models, mechanisms and clinical evidence for cancer dormancy [J].
Aguirre-Ghiso, Julio A. .
NATURE REVIEWS CANCER, 2007, 7 (11) :834-846
[3]   Intravascular origin of metastasis from the proliferation of endothelium-attached tumor cells: a new model for metastasis [J].
Al-Mehdi, AB ;
Tozawa, K ;
Fisher, AB ;
Shientag, L ;
Lee, A ;
Muschel, RJ .
NATURE MEDICINE, 2000, 6 (01) :100-102
[4]   Reduced metastasis of transgenic mammary cancer in urokinase-deficient mice [J].
Almholt, K ;
Lund, LR ;
Rygaard, J ;
Nielsen, BS ;
Dano, K ;
Romer, J ;
Johnsen, M .
INTERNATIONAL JOURNAL OF CANCER, 2005, 113 (04) :525-532
[5]   Interleukin-6 in the Bone Marrow Microenvironment Promotes the Growth and Survival of Neuroblastoma Cells [J].
Ara, Tasnim ;
Song, Liping ;
Shimada, Hiroyuki ;
Keshelava, Nino ;
Russell, Heidi V. ;
Metelitsa, Leonid S. ;
Groshen, Susan G. ;
Seeger, Robert C. ;
DeClerck, Yves A. .
CANCER RESEARCH, 2009, 69 (01) :329-337
[6]   The endothelin axis in cancer [J].
Bagnato, Anna ;
Rosano, Laura .
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY, 2008, 40 (08) :1443-1451
[7]   Chemokine biology in cancer [J].
Balkwill, F .
SEMINARS IN IMMUNOLOGY, 2003, 15 (01) :49-55
[8]   Modes of resistance to anti-angiogenic therapy [J].
Bergers, Gabriele ;
Hanahan, Douglas .
NATURE REVIEWS CANCER, 2008, 8 (08) :592-603
[9]  
Bertolini F, 2003, CANCER RES, V63, P4342
[10]   The multifaceted circulating endothelial cell in cancer: towards marker and target identification [J].
Bertolini, Francesco ;
Shaked, Yuval ;
Mancuso, Patrizia ;
Kerbel, Robert S. .
NATURE REVIEWS CANCER, 2006, 6 (11) :833-845