C/EBPβ is required for 'emergency' granulopoiesis

被引：341

作者：

Hirai, Hideyo

Zhang, Pu

Dayaram, Tajhal

Hetherington, Christopher J.

Mizuno, Shin-ichi

Imanishi, Jiro

Akashi, Koichi

Tenen, Daniel G. ^{[1
]}

机构：

[1] Harvard Univ, Inst Med, Boston, MA 02115 USA

[2] Harvard Univ, Stem Cell Inst, Boston, MA 02115 USA

[3] Kyoto Prefectural Univ Med, Dept Microbiol, Kyoto 602, Japan

[4] Harvard Univ, Sch Med, Dana Farber Canc Inst, Dept Canc Immunol & AIDS, Boston, MA 02115 USA

[5] Kyushu Univ Hosp, Ctr Cellular & Mol Med, Fukuoka 8120034, Japan

来源：

NATURE IMMUNOLOGY | 2006年 / 7卷 / 07期

关键词：

D O I：

10.1038/ni1354

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

During 'emergency' situations such as infections, host defense requires rapid mobilization of bone marrow granulocyte progenitors. 'Steady-state' granulopoiesis is absolutely dependent on the C/EBP alpha transcription factor, but the transcriptional mechanisms underlying emergency granulopoiesis remain unclear. Here we show that large numbers of granulocytes were generated from C/EBP alpha-deficient progenitors after cytokine stimulation in vivo. Cytokine treatment or fungal infection induced upregulation of C/EBP beta but not C/EBP alpha or C/EBP epsilon transcripts in granulocyte progenitors, and C/EBP beta-deficient progenitors showed decreased emergency-induced granulopoiesis in vitro and in vivo. C/EBPb inhibited proliferation less severely than did C/EBP alpha. These data suggest a critical function for C/EBP beta in emergency granulopoiesis, which demands both differentiation and proliferation of granulocyte precursors.

引用

页码：732 / 739

页数：8

共 60 条

[1] A clonogenic common myeloid progenitor that gives rise to all myeloid lineages [J].