The pivotal role of phosphatidylinositol 3-kinase-Akt signal transduction in virus survival

被引:191
作者
Cooray, S
机构
[1] Hlth Protect Agcy, Neurol & Resp Virus Lab, London NW9 5HT, England
[2] Guys Kings & St Thomas Sch Med, Virol Sect, Det Infect, St Thomas Hosp, London SE1 7EH, England
关键词
D O I
10.1099/vir.0.19771-0
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
Over the course of evolution, viruses have developed the ability to modulate a variety of host cell signalling pathways. Inhibition of apoptosis, in particular, has become recognized as an important contributory factor in virus survival. Apoptotic inhibition contributes to the establishment of latent and chronic infections and has been implicated in viral oncogenesis. The phosphatidylinositol 3-kinase (Pl3K)-Akt pathway is utilized by many cell types for inhibition of apoptosis and cellular survival. Virus modulation of this pathway provides an alternative to the expression of viral oncogenes or the direct inhibition of pro-apoptotic proteins. It has become evident that many viruses require up-regulation of this pathway to sustain long-term infections and it is modulated, in some cases, by specific viral products to create an environment favourable for cellular transformation. In other cases, Pl3K-Akt signalling simply helps to create an environment favourable for virus replication and virion assembly. This review details the modulation and function of Pl3K-Akt signalling for virus survival.
引用
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页码:1065 / 1076
页数:12
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