Cloning of a novel signal-transducing adaptor molecule containing an SH3 domain and ITAM

被引：72

作者：

Takeshita, T

Arita, T

Asao, H

Tanaka, N

Higuchi, M

Kuroda, H

Kaneko, K

Munakata, H

Endo, Y

Fujita, T

Sugamura, K

机构：

[1] TOHOKU UNIV,SCH MED,DEPT MICROBIOL,AOBA KU,SENDAI,MIYAGI 98077,JAPAN

[2] TOHOKU UNIV,SCH MED,DEPT BIOCHEM,AOBA KU,SENDAI,MIYAGI 98077,JAPAN

[3] FUKUSHIMA MED COLL,DEPT BIOCHEM,FUKUSHIMA 96012,JAPAN

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1996年 / 225卷 / 03期

基金：

日本科学技术振兴机构;

关键词：

D O I：

10.1006/bbrc.1996.1290

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We molecularly cloned a cDNA coding for a novel phosphotyrosine molecule with a 70 kDa molecular mass, named STAM (signal transducing adaptor molecule), which is tyrosine-phosphorylated rapidly after stimulation with various cytokines such as IL-2, IL-3, IL-4, IL-7, GM-CSF, EGF and PDGF. STAM contains an SH3 (Src-homology 3) domain and the ITAM (immunoreceptor tyrosine-based activation motif), suggesting that STAM acts as an adaptor molecule involved in signal transducing pathways from the cytokine receptors. (C) 1996 Academic Press, Inc.

引用

页码：1035 / 1039

页数：5

共 17 条

[1] INTERLEUKIN 2-INDUCED ACTIVATION OF JAK3 - POSSIBLE INVOLVEMENT IN SIGNAL-TRANSDUCTION FOR C-MYC INDUCTION AND CELL-PROLIFERATION
ASAO, H
TANAKA, N
ISHII, N
HIGUCHI, M
TAKESHITA, T
NAKAMURA, M
SHIRASAWA, T
SUGAMURA, K
[J]. FEBS LETTERS, 1994, 351 (02) : 201 - 206
[2] CAMBIER JC, 1994, ANNU REV IMMUNOL, V12, P457, DOI 10.1146/annurev.immunol.12.1.457
[3] REGIONAL LOCALIZATION OF THE GENE FOR THYROID PEROXIDASE TO HUMAN-CHROMOSOME 2P25 AND MOUSE CHROMOSOME 12C
ENDO, Y
ONOGI, S
UMEKI, K
YAMAMOTO, I
KOTANI, T
OHTAKI, S
FUJITA, T
[J]. GENOMICS, 1995, 25 (03) : 760 - 761
[4] Different interleukin 2 receptor beta-chain tyrosines couple to at least two signaling pathways and synergistically mediate interleukin 2-induced proliferation
Friedman, MC
Migone, TS
Russell, SM
Leonard, WJ
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1996, 93 (05) : 2077 - 2082
[5] ACTIVATION OF STAT5 BY INTERLEUKIN-2 REQUIRES A CARBOXYL-TERMINAL REGION OF THE INTERLEUKIN-2 RECEPTOR-BETA CHAIN BUT IS NOT ESSENTIAL FOR THE PROLIFERATIVE SIGNAL TRANSMISSION
FUJII, H
NAKAGAWA, Y
SCHINDLER, U
KAWAHARA, A
MORI, H
GOUILLEUX, F
GRONER, B
IHLE, JN
MINAMI, Y
MIYAZAKI, T
TANIGUCHI, T
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1995, 92 (12) : 5482 - 5486
[6] Dispensability of Jak1 tyrosine kinase for interleukin-2-induced cell growth signaling in a human T cell line
Higuchi, M
Asao, H
Tanaka, N
Oda, K
Takeshita, T
Nakamura, M
VanSnick, J
Sugamura, K
[J]. EUROPEAN JOURNAL OF IMMUNOLOGY, 1996, 26 (06) : 1322 - 1327
[7] CLONING AND SEQUENCE-ANALYSIS OF BETA-4 CDNA - AN INTEGRIN SUBUNIT THAT CONTAINS A UNIQUE 118 KD CYTOPLASMIC DOMAIN
HOGERVORST, F
KUIKMAN, I
VONDEMBORNE, AEGK
SONNENBERG, A
[J]. EMBO JOURNAL, 1990, 9 (03) : 765 - 770
[8] STATs: Signal transducers and activators of transcription
Ihle, JN
[J]. CELL, 1996, 84 (03) : 331 - 334
[9] THE SH2 AND SH3 DOMAIN CONTAINING PROTEIN GRB2 LINKS RECEPTOR TYROSINE KINASES TO RAS SIGNALING
LOWENSTEIN, EJ
DALY, RJ
BATZER, AG
LI, W
MARGOLIS, B
LAMMERS, R
ULLRICH, A
SKOLNIK, EY
BARSAGI, D
SCHLESSINGER, J
[J]. CELL, 1992, 70 (03) : 431 - 442
[10] CLONING OF ASH, A UBIQUITOUS PROTEIN COMPOSED OF ONE SRC HOMOLOGY REGION (SH)-2 AND 2 SH3 DOMAINS, FROM HUMAN AND RAT CDNA LIBRARIES
MATUOKA, K
SHIBATA, M
YAMAKAWA, A
TAKENAWA, T
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1992, 89 (19) : 9015 - 9019

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