Does methotrexate increase the risk of infection or malignancy?

被引:52
作者
Kanik, KS
Cash, JM
机构
[1] CLEVELAND CLIN FDN, DEPT GEN INTERNAL MED A91, CLEVELAND, OH 44195 USA
[2] CLEVELAND CLIN FDN, DEPT RHEUMAT & IMMUNOL DIS, CLEVELAND, OH 44195 USA
[3] UNIV S FLORIDA, SCH MED, DEPT MED, TAMPA, FL 33620 USA
关键词
D O I
10.1016/S0889-857X(05)70368-9
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Most patients do not exhibit overt signs of immunosuppression. Studies cited in this article support a modest increase in the rate of bacterial respiratory and skin infections. Opportunistic infections occur rarely, however, and may be life threatening. The case for MTX carcinogenicity is less clear. The risk for malignancy other than lymphoproliferative disorders does not seem to be elevated, although multiple sporadic malignancies have been reported in treated patients. MTX is a superb agent for the therapy of a large group of immune-mediated diseases. Although an increased risk for infection and possible malignancy exists, the risk is small compared with the potential clinical benefit.
引用
收藏
页码:955 / +
页数:1
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