Desymmetrization by ring-closing metathesis leading to 6,8-dioxabicyclo[3.2.1]octanes:: A new route for the synthesis of (+)-exo- and endo-brevicomin

被引：35

作者：

Burke, SD ^{[1
]}

Müller, N ^{[1
]}

Beaudry, CM ^{[1
]}

机构：

[1] Univ Wisconsin, Dept Chem, Madison, WI 53706 USA

来源：

ORGANIC LETTERS | 1999年 / 1卷 / 11期

关键词：

D O I：

10.1021/ol9910971

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

[GRAPHICS] The 6,8-dioxabicyclo[3.2.1]octane skeleton is a common structural subunit in natural products. A conceptionally new strategy affording these structures is described for the syntheses of (+)-exo-brevicomin and rac-endo- and enantiomerically enriched (+) endo-brevicomin, employing desymmetrization of trienes derived from diols with C-2 and meso symmetry via ring closing metathesis.

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页码：1827 / 1829

页数：3

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