The 5α-reductase inhibitory components from heartwood of Artocarpus incisus:: Structure-activity investigations

被引：53

作者：

Shimizu, K ^{[1
]}

Fukuda, M ^{[1
]}

Kondo, R ^{[1
]}

Sakai, K ^{[1
]}

机构：

[1] Kyushu Univ, Fac Agr, Dept Forest Prod, Fukuoka 8128581, Japan

来源：

PLANTA MEDICA | 2000年 / 66卷 / 01期

关键词：

Artocarpus incisus L. f; Moraceae; heartwood; 5 alpha-reductase inhibitor; structure-activity relationship;

D O I：

10.1055/s-2000-11114

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

The methanol extract of heartwood of Artocarpus incisus showed potent 5 alpha-reductase inhibitory activity. We investigated the 5 alpha-reductase inhibitory effects of nine compounds isolated from A. incisus, Chlorophorin (IC50 = 37 mu M) and artocarpin (IC50 = 85 mu M) showed more potent inhibitory effects than did alpha-linolenic acid, which is known as a naturally occurring potent inhibitor. Structure-activity investigations suggested that the presence of an isoprene substituent (prenyl and geranyl) would enhance 5 alpha-reductase inhibitory effects.

引用

页码：16 / 19

页数：4

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