Signaling pathway of MAPK/ERK in cell proliferation, differentiation, migration, senescence and apoptosis

被引：2224

作者：

Sun, Yu ^{[1
]}

Liu, Wen-Zhou ^{[1
]}

Liu, Tao ^{[1
]}

Feng, Xu ^{[1
]}

Yang, Nuo ^{[1
]}

Zhou, Hua-Fu ^{[1
]}

机构：

[1] GuangXi Med Univ, Affiliated Hosp 1, Dept Cardiothorac Surg, Nanning 530021, Peoples R China

来源：

JOURNAL OF RECEPTORS AND SIGNAL TRANSDUCTION | 2015年 / 35卷 / 06期

关键词：

Extracellular signal-regulated kinase; mitogen-activated protein kinases; signaling pathway; TRAIL-INDUCED APOPTOSIS; FAS-MEDIATED APOPTOSIS; REGULATED KINASE ERK; BREAST-CANCER CELLS; OXIDATIVE STRESS; EPITHELIAL-CELLS; DOWN-REGULATION; MC3T3-E1; CELLS; ACTIVATION; PROTECTS;

D O I：

10.3109/10799893.2015.1030412

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

The generic mitogen-activated protein kinases (MAPK) signaling pathway is shared by four distinct cascades, including the extracellular signal-related kinases (ERK1/2), Jun amino-terminal kinases (JNK1/2/3), p38-MAPK and ERK5. Mitogen-activated protein kinases/extracellular signal-regulated kinase (MAPK/ERK) pathway is reported to be associated with the cell proliferation, differentiation, migration, senescence and apoptosis. The literatures were searched extensively and this review was performed to review the role of MAPK/ERK signaling pathway in cell proliferation, differentiation, migration, senescence and apoptosis.

引用

收藏

页码：600 / 604

页数：5

相关论文

共 77 条

[1]

Anderson CNG, 1999, J NEUROSCI, V19, P664

[2]

HLA-DR signaling inhibits Fas-mediated apoptosis in A375 melanoma cells [J].

Aoudjit, F ;

Guo, WY ;

Gagnon-Houde, JV ;

Castaigne, JG ;

Alcaide-Loridan, C ;

Charron, D ;

Al-Daccak, R .

EXPERIMENTAL CELL RESEARCH, 2004, 299 (01) :79-90

[3]

The LRRK2 G2019S mutant exacerbates basal autophagy through activation of the MEK/ERK pathway [J].

Bravo-San Pedro, Jose M. ;

Niso-Santano, Mireia ;

Gomez-Sanchez, Ruben ;

Pizarro-Estrella, Elisa ;

Aiastui-Pujana, Ana ;

Gorostidi, Ana ;

Climent, Vicente ;

Lopez de Maturana, Rakel ;

Sanchez-Pernaute, Rosario ;

Lopez de Munain, Adolfo ;

Fuentes, Jose M. ;

Gonzalez-Polo, Rosa A. .

CELLULAR AND MOLECULAR LIFE SCIENCES, 2013, 70 (01) :121-136

[4]

Sorafenib Inhibits Lymphoma Xenografts by Targeting MAPK/ERK and AKT Pathways in Tumor and Vascular Cells [J].

Carlo-Stella, Carmelo ;

Locatelli, Silvia L. ;

Giacomini, Arianna ;

Cleris, Loredana ;

Saba, Elena ;

Righi, Marco ;

Guidetti, Anna ;

Gianni, Alessandro M. .

PLOS ONE, 2013, 8 (04)

[5]

Allicin inhibits cell growth and induces apoptosis in U87MG human glioblastoma cells through an ERK-dependent pathway [J].

Cha, Jae Hun ;

Choi, Yoon Ji ;

Cha, Seung Heon ;

Choi, Chang Hwa ;

Cho, Won Ho .

ONCOLOGY REPORTS, 2012, 28 (01) :41-48

[6]

Mesothelin enhances invasion of ovarian cancer by inducing MMP-7 through MAPK/ERK and JNK pathways [J].

Chang, Ming-Cheng ;

Chen, Chi-An ;

Chen, Pao-Jen ;

Chiang, Ying-Cheng ;

Chen, Yu-Li ;

Mao, Tsui-Lien ;

Lin, Han-Wei ;

Chiang, Wen-Hsien Lin ;

Cheng, Wen-Fang .

BIOCHEMICAL JOURNAL, 2012, 442 :293-302

[7]

Local Anesthetics Induce Apoptosis in Human Thyroid Cancer Cells through the Mitogen-Activated Protein Kinase Pathway [J].

Chang, Yuan-Ching ;

Hsu, Yi-Chiung ;

Liu, Chien-Liang ;

Huang, Shih-Yuan ;

Hu, Meng-Chun ;

Cheng, Shih-Ping .

PLOS ONE, 2014, 9 (02)

[8]

Vasopressin Protects Hippocampal Neurones in Culture Against Nutrient Deprivation or Glutamate-Induced Apoptosis [J].

Chen, J. ;

Aguilera, G. .

JOURNAL OF NEUROENDOCRINOLOGY, 2010, 22 (10) :1072-1081

[9]

Injury-induced activation of the MAPK/CREB pathway triggers apoptosis-induced compensatory proliferation in hydra head regeneration [J].

Chera, Simona ;

Ghila, Luiza ;

Wenger, Yvan ;

Galliot, Brigitte .

DEVELOPMENT GROWTH & DIFFERENTIATION, 2011, 53 (02) :186-201

[10]

Proteasome inhibition-induced p38 MAPK/ERK signaling regulates autophagy and apoptosis through the dual phosphorylation of glycogen synthase kinase 3β [J].

Choi, Cheol-Hee ;

Lee, Byung-Hoon ;

Ahn, Sang-Gun ;

Oh, Seon-Hee .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2012, 418 (04) :759-764

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