Simultaneous glyburide/metformin therapy is superior to component monotherapy as an initial pharmacological treatment for type 2 diabetes

被引:95
作者
Garber, AJ
Larsen, J
Schneider, SH
Piper, BA
Henry, D
机构
[1] Baylor Coll Med, Houston, TX 77030 USA
[2] Methodist Hosp, Houston, TX 77030 USA
[3] Univ Nebraska, Med Ctr DEM, Omaha, NE USA
[4] Robert Wood Johnson Univ Hosp, New Brunswick, NJ USA
[5] Bristol Myers Squibb Co, Pharmaceut Res Inst, Princeton, NJ 08543 USA
关键词
type; 2; diabetes; glyburide; metformin; glycaemic control; combination glyburide/metformin therapy/glibenclamide;
D O I
10.1046/j.1463-1326.2002.00211.x
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Objective: To evaluate whether simultaneous initial treatment of both insulin resistance and impaired beta-cell insulin secretion with glyburide/metformin tablets is superior to monotherapy with each component agent. Research Design and Methods: In this randomized, parallel-group, placebo-controlled, multicentre study, 806 patients with type. 2 diabetes (mean duration, 3 years) who had failed diet and exercise were randomly assigned to 4 weeks of therapy with placebo, glyburide 2.5 mg, metformin 500 mg, glyburide/metformin 1.25/250 mg, or glyburide/ metformin 2.5/500 mg once daily, Doses were then titrated over 8 weeks based on glycaemic response, The primary outcome measure was change from baseline in mean HbA(1c), after 20 weeks. Changes in fasting plasma glucose, lipids and body weight were also assessed along with 2-h postprandial glucose and insulin values after a standardized meal. Results: At week 20, patients taking glyburide/metformin 1.25/250 mg or 2,5/500 mg tablets had greater reductions in HbA(1c), levels (-1.48% and -1.53% respectively) compared with placebo (-0.21%; both p < 0.001), glyburide (-1.24%; p = 0.016 and p = 0.004 respectively) or metformin (-1.03%; both p < 0,001). Fasting plasma glucose concentrations were reduced more in both glyburide/metformin groups compared with placebo and metformin (p <0.001); patients in both combination therapy groups also had significantly lower postprandial glucose concentrations compared with placebo, glyburide and metformin. Conclusions: Initial combination treatment with glyburide/metformin tablets produces greater improvements in glycaemic control than either glyburide or metformin monotherapy. The superiority of initial therapy with glyburide/ metformin tablets may arise from simultaneous treatment of both pathophysiological defects of type 2 diabetes.
引用
收藏
页码:201 / 208
页数:8
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