Targeting the ubiquitin system in cancer therapy

被引：504

作者：

Hoeller, Daniela ^{[2
]}

Dikic, Ivan ^{[1
,3
,4
]}

机构：

[1] Univ Frankfurt, Inst Biochem & Cluster Excellence Macromol Comple, D-60590 Frankfurt, Germany

[2] Innsbruck Med Univ, Div Med Biochem, A-6020 Innsbruck, Austria

[3] Mediterranean Inst Life Sci, Tumor Biol Program, Split 21000, Croatia

[4] Univ Split, Sch Med, Dept Immunol, Split 21000, Croatia

来源：

NATURE | 2009年 / 458卷 / 7237期

关键词：

ACTIVE PROTEASOME INHIBITOR; TUMOR-SUPPRESSOR PROTEIN; KAPPA-B ACTIVATION; P53 NUCLEAR EXPORT; DEUBIQUITINATING ENZYMES; DEPENDENT APOPTOSIS; MULTIPLE-MYELOMA; BINDING DOMAINS; DNA-DAMAGE; LIGASE;

D O I：

10.1038/nature07960

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The ubiquitin system is a network of proteins dedicated to the ubiquitylation of cellular targets and the subsequent control of numerous cellular functions. The deregulation of components of this elaborate network leads to human pathogenesis, including the development of many types of tumour. Alterations in the ubiquitin system that occur during the initiation and progression of cancer are now being uncovered, and this knowledge is starting to be exploited for both molecular diagnostics and the development of novel strategies to combat cancer.

引用

页码：438 / 444

页数：7

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