cAMP regulates vasopressin-induced AQP2 expression via protein kinase A-independent pathway

被引：48

作者：

Umenishi, Fuminori

Narikiyo, Takefunii

Vandewalle, Alain

Schrier, Robert W.

机构：

[1] Univ Colorado, Hlth Sci Ctr, Div Renal Dis & Hypertens, Dept Med, Denver, CO 80262 USA

[2] Univ Colorado, Hlth Sci Ctr, Dept Physiol & Biophys, Denver, CO 80262 USA

[3] Univ Paris 07, INSERM U478, Paris, France

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES | 2006年 / 1758卷 / 08期

关键词：

aquaporin-2; arginine vasopressin; cAMP; ERK; CREB; PKA;

D O I：

10.1016/j.bbamem.2006.06.001

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The regulation of AVP-induced AQP2 expression was investigated in the present study. AVP administration induced AQP2 expression in a dose-dependent manner in association with an increase in intracellular cAMP concentration. PKA activity was stimulated by AVP but PKA inhibitors did not block the upregulation of AQP2 expression. However, AVP also activated both ERK and CREB pathways, and ERK inhibitor attenuated the upregulation of AQP2 expression. These results therefore indicate that the effect of AVP stimulation to upregulate AQP2 expression involves a PKA-independent pathway. (c) 2006 Elsevier B.V. All rights reserved.

引用

页码：1100 / 1105

页数：6

共 21 条

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