Serum inhibin B levels measured early during FSH administration for IVF may be of value in predicting the number of oocytes to be retrieved in normal and low responders

被引:24
作者
Eldar-Geva, T
Margalioth, EJ
Ben-Chetrit, A
Gal, M
Robertson, DM
Healy, DL
Diamant, YZ
Spitz, IM
机构
[1] Ben Gurion Univ Negev, Shaare Zedek Med Ctr, IVF Unit, Dept Obstet & Gynecol, IL-91031 Jerusalem, Israel
[2] Ben Gurion Univ Negev, Shaare Zedek Med Ctr, Hormone Res Inst, IL-91031 Jerusalem, Israel
[3] Prince Henrys Inst Med Res, Melbourne, Vic, Australia
[4] Monash Med Ctr, Dept Obstet & Gynaecol, Melbourne, Vic, Australia
关键词
inhibin A; inhibin B; IVF; low responders; oocyte number;
D O I
10.1093/humrep/17.9.2331
中图分类号
R71 [妇产科学];
学科分类号
100211 ;
摘要
BACKGROUND: In a previous study we have found that in normal ovulatory women, serum inhibin B levels on days 4-6 of FSH administration correlated with the number of oocytes retrieved. In the current study we examined the significance of earlier inhibin B measurements in predicting the oocyte number, in both normal and low responders. METHODS: Study A consisted of 19 patients undergoing their first IVF cycle (n = 10) or had a normal response (box with v6 oocytes retrieved, n = 9), while study B consisted of 15 patients with a previous low ovarian response (less than or equal to5 oocytes retrieved). All patients had day 3 FSH levels <10 IU/l. After pituitary suppression, 300 (study A) or 600 IU (study B) of pure FSH was administered daily. Serum FSH, inhibin A, inhibin B and estradiol (E-2) were determined prior to and every 1-2 days throughout FSH treatment. RESULTS: Study A: oocyte number between 4 and 14 correlated significantly with serum inhibin B levels on all days of FSH treatment, and with inhibin A and E-2 late during treatment. No correlation was found between inhibin B and when oocyte number was >16. Study B: oocyte number correlated significantly with inhibin B and inhibin A on all days of FSH treatment, even on day 2 (r = 0.90, P < 0.001 and r = 0.65, P < 0.05 for inhibin B and A respectively). No significant correlation was found with E-2 levels. In both studies, all patients with inhibin B >100 pg/ml on treatment day 2 had >6 oocytes. CONCLUSIONS: Our data suggest that serum inhibin B measured early during FSH stimulation may indicate whether sufficient oocytes will be retrieved, in both normal and low responders. Serum inhibin B measured during early FSH treatment may be of predictive value in monitoring ovarian stimulation treatment for IVF.
引用
收藏
页码:2331 / 2337
页数:7
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