Osmotic nephrosis due to high-dose immunoglobulin therapy containing sucrose (but not with glycine) in a patient with immunoglobulin A nephritis

被引：61

作者：

HansenSchmidt, S ^{[1
]}

Silomon, J ^{[1
]}

Keller, F ^{[1
]}

机构：

[1] UNIV HOSP,DEPT INTERNAL MED,DIV NEPHROL,ULM,GERMANY

来源：

AMERICAN JOURNAL OF KIDNEY DISEASES | 1996年 / 28卷 / 03期

关键词：

acute renal failure; immunoglobulin; immunoglobulin A nephritis; osmotic nephrosis; sucrose; glycine; vacuolization;

D O I：

10.1016/S0272-6386(96)90505-3

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Acute renal failure has been described as a complication of immunoglobulin therapy. It is not clear whether the immunoglobulin per se or the sucrose that is used as a stabilizer is the cause. We describe a patient with immunoglobulin A nephropathy who was treated with sucrose-containing immunoglobulin. He developed acute renal failure with osmotic nephrosis found on kidney biopsy. When using a glycine-containing immunoglobulin no acute renal impairment was observed in this patient. (C) 1996 by the National Foundation, Inc.

引用

页码：451 / 453

页数：3

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