Immunomodulatory effects of arabinogalactan-proteins from Baptisia and Echinacea

被引：53

作者：

Classen, B.

Thude, S.

Blaschek, W.

Wack, M.

Bodinet, C.

机构：

[1] Univ Kiel, Inst Pharm, Dept Pharmaceut Sci, D-24118 Kiel, Germany

[2] Schaper & Brummer GmbH & Co KG, D-38259 Salzgitter, Germany

来源：

PHYTOMEDICINE | 2006年 / 13卷 / 9-10期

关键词：

Baptisia tinctoria; Echinacea pallida; Echinacea purpurea; arabinogalactan-protein; immunomodulatory effect;

D O I：

10.1016/j.phymed.2005.10.004

中图分类号：

Q94 [植物学];

学科分类号：

071001 [植物学];

摘要：

The influences of different arabinogalactan-proteins (AGPs) on proliferation and IgM-production of mouse lymphocytes as well as nitrite- and IL6-production of mouse macrophages were investigated in vitro. AGPs have been isolated and purified from roots of Baptisia tinctoria and Echinacea pallida and suspension culture of Echinacea purpurea. Comparing the AGPs, there are differences with regard to fine structure as well as to activities. AGPs from roots of B. tinctoria and E pallida show high activity in all test systems. AGP from cell culture of E purpurea shows no influence on proliferation of mouse lymphocytes, only weak influence on the IgM-production of mouse lymphocytes and weak stimulation of nitrite- and IL6-production in alveolar mouse macrophage culture. (c) 2005 Elsevier GmbH. All rights reserved.

引用

页码：688 / 694

页数：7

共 20 条

[1]

Differentiation between the complement modulating effects of an arabinogalactan-protein from Echinacea purpurea and heparin [J].