Whole-genome integrative analysis reveals expression signatures predicting transformation in follicular lymphoma

被引：51

作者：

Brodtkorb, Marianne ^{[1
,2
,3
,4
]}

Lingjaerde, Ole Christian ^{[1
,5
]}

Huse, Kanutte ^{[1
,3
]}

Troen, Gunhild ^{[6
]}

Hystad, Marit ^{[1
,3
]}

Hilden, Vera I. ^{[1
,3
]}

Myklebust, June H. ^{[1
,3
]}

Leich, Ellen ^{[7
,8
]}

Rosenwald, Andreas ^{[7
,8
]}

Delabie, Jan ^{[6
]}

Holte, Harald ^{[1
,4
]}

Smeland, Erlend B. ^{[1
,3
]}

机构：

[1] Oslo Univ Hosp, Ctr Canc Biomed, Oslo, Norway

[2] Univ Oslo, Fac Med, Oslo, Norway

[3] Oslo Univ Hosp, Dept Immunol, Inst Canc Res, Oslo, Norway

[4] Oslo Univ Hosp, Dept Oncol, Div Canc Med Surg & Transplantat, Oslo, Norway

[5] Univ Oslo, Dept Comp Sci, Sect Biomed Informat, Oslo, Norway

[6] Oslo Univ Hosp, Dept Pathol, Oslo, Norway

[7] Univ Wurzburg, Inst Pathol, Wurzburg, Germany

[8] Comprehens Canc Ctr Wurzburg, Wurzburg, Germany

来源：

BLOOD | 2014年 / 123卷 / 07期

关键词：

B-CELL LYMPHOMA; GENE-EXPRESSION; COPY NUMBER; SURVIVAL; TRANSLOCATION; PROFILES; PATHWAYS; KINASE;

D O I：

10.1182/blood-2013-07-512392

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

Transformation of follicular lymphoma (FL) to a more aggressive disease is associated with rapid progression and death. Existing molecular markers for transformation are few and their clinical impact is limited. Here, we report on a whole-genome study of DNA copy numbers and gene expression profiles in serial FL biopsies. We identified 698 genes with high correlation between gene expression and copy number, and the molecular network most enriched for these cis-associated genes. This network includes 14 cis-associated genes directly related to the nuclear factor kappa B (NF-kappa B) pathway. For each of these 14 genes, the correlated NF-kB target genes were identified and corresponding expression scores were defined. The scores for 6 of the cis-associated NFkB pathway genes (BTK, IGBP1, IRAK1, ROCK1, TMED7-TICAM2, and TRIM37) were significantly associated with transformation. The results suggest that genes regulating B-cell survival and activation are involved in transformation of FL.

引用

页码：1051 / 1054

页数：4

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