A functionalized, deep cavitand catalyzes the aminolysis of a choline derivative

被引：57

作者：

Gissot, A

Rebek, J

机构：

[1] Scripps Res Inst, Skaggs Inst Chem Biol, La Jolla, CA 92037 USA

[2] Scripps Res Inst, Dept Chem, La Jolla, CA 92037 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2004年 / 126卷 / 24期

关键词：

D O I：

10.1021/ja049074r

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The aminolysis of choline p-nitrophenyl carbonate is catalyzed with turnover by a deep cavitand bearing an introverted pyridone function. The synergy of action between the recognition of the guest in the binding pocket and the catalytic activity brought to bear by the pyridone is responsible for the high substrate specificity observed. Copyright © 2004 American Chemical Society.

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页码：7424 / 7425

页数：2

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