Nasal bone assessment in prenatal screening for trisomy 21

被引：128

作者：

Sonek, J. D.

Cicero, S.

Neiger, R.

Nicolaides, K. H.

机构：

[1] Ohio State Univ, Dept Obstet & Gynecol, Dayton, OH USA

[2] Wright State Univ, Dept Obstet & Gynecol, Dayton, OH 45435 USA

[3] Fetal Med Fdn, London, England

[4] Kings Coll Hosp London, Harris Birthright Res Ctr Fetal Med, London, England

来源：

AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY | 2006年 / 195卷 / 05期

关键词：

nasal bone absence; nasal bone hypoplasia; trisomy; 21; chromosomal defects; ultrasound; X-ray; histomorphology; prenatal screening;

D O I：

10.1016/j.ajog.2005.11.042

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

A small nose is a common facial feature of individuals with trisomy 21. Evidence based on radiologic, histomorphologic, and sonographic studies shows that nasal bone abnormalities are significantly more common in trisomy 21 fetuses than in euploid fetuses. These abnormalities, which include both nasal bone absence and short nasal bone length, can be detected by prenatal ultrasound. In this article we review the evidence and discuss the potential value of assessment of the fetal nasal bone in screening for trisomy 21. (c) 2006 Mosby, Inc. All rights reserved.

引用

页码：1219 / 1230

页数：12

共 57 条

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