Intermolecular N-alkylation of amines under conditions of the Mitsunobu reaction:: a new solid-phase synthesis of tertiary benzylamines

被引：18

作者：

Zaragoza, F ^{[1
]}

Stephensen, H ^{[1
]}

机构：

[1] Novo Nordisk AS, DK-2760 Malov, Denmark

来源：

TETRAHEDRON LETTERS | 2000年 / 41卷 / 11期

关键词：

amino acids and derivatives; benzylation; Mitsunobu reactions; solid-phase synthesis;

D O I：

10.1016/S0040-4039(00)00028-9

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Support-bound secondary aliphatic amines can be N-benzylated with benzyl alcohols under the standard conditions of the Mitsunobu reaction if the amine is converted into the corresponding ammonium iodide salt prior to Mitsunobu reaction. (C) 2000 Elsevier Science Ltd. All rights reserved.

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页码：1841 / 1844

页数：4

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