AP-1: One switch for many signals

被引：334

作者：

Wisdom, R ^{[1
]}

机构：

[1] Vanderbilt Univ, Dept Biochem, Nashville, TN 37232 USA

来源：

EXPERIMENTAL CELL RESEARCH | 1999年 / 253卷 / 01期

关键词：

D O I：

10.1006/excr.1999.4685

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The transcription factor AP-1 is activated in response to an incredible array of stimuli, including mitogenic growth factors, inflammatory cytokines, growth factors of the TGF-beta family, UV and ionizing irradiation, cellular stress, antigen binding, and neoplastic transformation. In this review, I discuss genetic evidence that supports a role for AP-1 in the cellular response to some of these stimuli and describe biochemical properties that might explain the ability of this transcription factor to activate different sets of genes in response to different stimuli. (C) 1999 Academic Press.

引用

页码：180 / 185

页数：6

共 31 条

[1] ACTIVATION OF CAMP AND MITOGEN RESPONSIVE GENES RELIES ON A COMMON NUCLEAR FACTOR [J].

ARIAS, J ;

ALBERTS, AS ;

BRINDLE, P ;

CLARET, FX ;

SMEAL, T ;

KARIN, M ;

FERAMISCO, J ;

MONTMINY, M .

NATURE, 1994, 370 (6486) :226-229

[2] CBP-INDUCED STIMULATION OF C-FOS ACTIVITY IS ABROGATED BY E1A [J].

BANNISTER, AJ ;

KOUZARIDES, T .

EMBO JOURNAL, 1995, 14 (19) :4758-4762

[3] Fos family members induce cell cycle entry by activating cyclin D1 [J].

Brown, JR ;

Nigh, E ;

Lee, RJ ;

Ye, H ;

Thompson, MA ;

Saudou, F ;

Pestell, RG ;

Greenberg, ME .

MOLECULAR AND CELLULAR BIOLOGY, 1998, 18 (09) :5609-5619

[4] Structure of the DNA binding domains from NFAT, Fos and Jun bound specifically to DNA [J].

Chen, L ;

Glover, JNM ;

Hogan, PG ;

Rao, A ;

Harrison, SC .

NATURE, 1998, 392 (6671) :42-48

[5] JUN-B DIFFERS IN ITS BIOLOGICAL PROPERTIES FROM, AND IS A NEGATIVE REGULATOR OF, C-JUN [J].

CHIU, R ;

ANGEL, P ;

KARIN, M .

CELL, 1989, 59 (06) :979-986

[6] Inhibitory and activating functions for MAPK Kss1 in the S-cerevisiae filamentous-growth signalling pathway [J].

Cook, JG ;

Bardwell, L ;

Thorner, J .

NATURE, 1997, 390 (6655) :85-88

[7] C-FOS TRANSCRIPTIONAL ACTIVITY STIMULATED BY H-RAS-ACTIVATED PROTEIN-KINASE DISTINCT FROM JNK AND ERK [J].

DENG, TL ;

KARIN, M .

NATURE, 1994, 371 (6493) :171-175

[8] THE COLLAGENASE GENE PROMOTER CONTAINS A TPA AND ONCOGENE-RESPONSIVE UNIT ENCOMPASSING THE PEA3 AND AP-1 BINDING-SITES [J].

GUTMAN, A ;

WASYLYK, B .

EMBO JOURNAL, 1990, 9 (07) :2241-2246

[9] IDENTIFICATION OF AN ONCOPROTEIN-RESPONSIVE AND UV-RESPONSIVE PROTEIN-KINASE THAT BINDS AND POTENTIATES THE C-JUN ACTIVATION DOMAIN [J].

HIBI, M ;

LIN, AN ;

SMEAL, T ;

MINDEN, A ;

KARIN, M .

GENES & DEVELOPMENT, 1993, 7 (11) :2135-2148

[10] TARGETED DISRUPTION OF THE C-FOS GENE DEMONSTRATES C-FOS-DEPENDENT AND C-FOS-INDEPENDENT PATHWAYS FOR GENE-EXPRESSION STIMULATED BY GROWTH-FACTORS OR ONCOGENES [J].

HU, ED ;

MUELLER, E ;

OLIVIERO, S ;

PAPAIOANNOU, VE ;

JOHNSON, R ;

SPIEGELMAN, BM .

EMBO JOURNAL, 1994, 13 (13) :3094-3103

← 1 2 3 4 →