1H and 13C NMR study of 2-hydroxyglutaric acid and its lactone

被引：37

作者：

Bal, D ^{[1
]}

Gryff-Keller, A ^{[1
]}

机构：

[1] Warsaw Univ Technol, Fac Chem, PL-00664 Warsaw, Poland

来源：

MAGNETIC RESONANCE IN CHEMISTRY | 2002年 / 40卷 / 08期

关键词：

NMR; H-1; C-13; 2-hydroxyglutaric aciduria; 5-oxotetrahydrofuran-2-carboxylic acid; lactonization;

D O I：

10.1002/mrc.1053

中图分类号：

O6 [化学];

学科分类号：

0703 [化学];

摘要：

Determination of the level and absolute configuration of 2-hydroxyglutaric acid in a patient's urine is a method of diagnosing two metabolic diseases. Such a determination can be done with the aid of NMR spectroscopic methods. In this paper the careful interpretation of H-1 and C-13 NMR spectra of this metabolite and its lactone measured under conditions used in biomedical assays is reported. The H-1 chemical shifts and spin-spin coupling constants were derived using the total lineshape analysis method. Copyright (C) 2002 John Wiley Sons, Ltd.

引用

页码：533 / 536

页数：4

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