Furanones as potential anti-bacterial coatings on biomaterials

被引:129
作者
Baveja, JK
Wilcox, MDP
Hume, EBH
Kumar, N
Odell, R
Poole-Warren, LA [1 ]
机构
[1] Univ New S Wales, Grad Sch Biomed Engn, Sydney, NSW 2052, Australia
[2] Univ New S Wales, Cooperat Res Ctr Eye Res & Technol, Sydney, NSW 2052, Australia
[3] Univ New S Wales, Ctr Marine Biofouling & Bioinnovat, Sydney, NSW 2052, Australia
关键词
biomaterials; anti-bacterial; biofilm; bacterial adhesion; surface modification;
D O I
10.1016/j.biomaterials.2004.02.051
中图分类号
R318 [生物医学工程];
学科分类号
0831 ;
摘要
A major barrier to the long-term use of medical devices is development of infection. Staphylococcus epidermidis is one of the most common bacterial isolates from these infections with biofilm formation being their main virulence factor. Currently, antibiotics are used as the main form of therapy. However with the emergence of staphylococcal resistance, this form of therapy is fast becoming ineffective. In this study, the ability of a novel furanone antimicrobial compound to inhibit S. epidermidis adhesion and slime production on biomaterials was assessed. Furanones were physically adsorbed to various biomaterials and bacterial load determined using radioactivity. Slime production was assessed using a colorimetric method. Additionally, the effect of the furanone coating on material surface characteristics such as hydrophobicity and surface roughness was also investigated. The results of this study indicated that there was no significant change in the material characteristics after furanone coating. Bacterial load on all furanone-coated materials was significantly reduced (p<0.001) as was slime production (p<0.001). There is a potential for furanone-coated biomaterials to be used to reduce medical device-associated infections. (C) 2004 Elsevier Ltd. All rights reserved.
引用
收藏
页码:5003 / 5012
页数:10
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