Stem Cells Loaded with Nanoparticles as a Drug Carrier for In Vivo Breast Cancer Therapy

被引：114

作者：

Cao, Binrui ^{[1
]}

Yang, Mingying ^{[2
]}

Zhu, Ye ^{[1
]}

Qu, Xuewei ^{[1
]}

Mao, Chuanbin ^{[1
]}

机构：

[1] Univ Oklahoma, Stephenson Life Sci Res Ctr, Dept Chem & Biochem, Norman, OK 73019 USA

[2] Zhejiang Univ, Coll Anim Sci, Inst Appl Bioresource Res, Hangzhou 310058, Zhejiang, Peoples R China

来源：

ADVANCED MATERIALS | 2014年 / 26卷 / 27期

基金：

美国国家卫生研究院; 美国国家科学基金会; 中国国家自然科学基金;

关键词：

PHOTODYNAMIC THERAPY; INTRACRANIAL GLIOMA; DELIVERY; GROWTH; TUMORS; VITRO; DIFFERENTIATION; NANOSTRUCTURES; PURPURIN-18; ENDOCYTOSIS;

D O I：

10.1002/adma.201401550

中图分类号：

O6 [化学];

学科分类号：

070301 [无机化学];

摘要：

A novel anti-cancer drug carrier, mesenchymal stem cells (MSCs) encapsulating drug-loaded hollow silica nanoparticles, is used to carry a photosensitizer drug and deliver it to breast tumors, due to the natural high tumor affinity of the MSCs, and inhibit tumor growth by photo dynamic therapy. This new strategy for delivering a photosensitizer to tumors by using tumor-affinitive MSCs addresses the challenge of the accumulation of photosensitizer drugs in tumors in photodynamic therapy.

引用

页码：4627 / +

页数：6

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