Immunolocalization of tumor necrosis factor-α expressing cells in recurrent aphthous ulcer lesions (RAU)

被引:94
作者
Natah, SS
Häyrinen-Immonen, R
Hietanen, J
Malmström, M
Konttinen, YT
机构
[1] Univ Helsinki, Inflammat Res Grp Tules Rynma, Inst Biomed, FIN-00014 Helsinki, Finland
[2] Univ Helsinki, Cent Hosp, Dept Med, Helsinki, Finland
[3] Univ Helsinki, Dept Oral Med, FIN-00014 Helsinki, Finland
[4] Univ Helsinki, Dept Oral Pathol, Inst Dent, FIN-00014 Helsinki, Finland
关键词
recurrent aphthous ulcers; tumor necrosis factor-alpha;
D O I
10.1034/j.1600-0714.2000.290104.x
中图分类号
R78 [口腔科学];
学科分类号
1003 [口腔医学];
摘要
Tumor necrosis factor (TNF)-alpha is a pro-inflammatory cytokine and crucial mediator in many aspects of immunity. Although several studies have shown that recurrent aphthous ulcers (RAU) can be prevented by treatment that prevents the synthesis of endogenous TNF-alpha, little is known about the location and distribution of TNF-alpha-expressing cells at disease sites. The aim of the present work is, therefore, to investigate TNF-alpha and its cellular distribution in RAU lesions compared with those in induced oral traumatic ulcers (TUs). Twelve biopsies of RAU lesions of oral mucosa were obtained from 12 patients with RAU. They were compared to a control group consisting of ten samples of induced TUs. All samples were analyzed for TNF-alpha expression by using monoclonal mouse anti-human TNF-alpha antibody in avidin-biotin-peroxidase complex (ABC) staining. Results were quantified by a semi-automatic VIDAS image analysis system. TNF-alpha immunoreactivity was contained mainly in monocyte/macrophages and lymphocytes within the mononuclear inflammatory infiltrates. TNF-alpha was often seen in mast cells and vascular endothelial cells in connective tissue lateral to the inflammatory infiltrates. Interestingly, 32%-60% of the mononuclear cells were found to be TNF-alpha immunoreactive in RAU lesions. TNF-alpha-containing cells were more numerous in aphthae (188 +/- 46 cells/0.2 mm(2)) compared with controls (52 +/- 14 cells/0.2 mm(2), P<0.001). These findings suggest that RAU lesions are characterized by high expression of TNF-alpha. Because such expression occurred in the mononuclear inflammatory cells, mast cells and vascular endothelial cells, TNF-alpha, which is a major inflammatory mediator, may contribute to the activation and recruitment of leukocytes that are found in RAU lesions.
引用
收藏
页码:19 / 25
页数:7
相关论文
共 42 条
[1]
ENDOTHELIAL LEUKOCYTE ADHESION MOLECULE-1 - AN INDUCIBLE RECEPTOR FOR NEUTROPHILS RELATED TO COMPLEMENT REGULATORY PROTEINS AND LECTINS [J].
BEVILACQUA, MP ;
STENGELIN, S ;
GIMBRONE, MA ;
SEED, B .
SCIENCE, 1989, 243 (4895) :1160-1165
[2]
Elevated levels of interferon gamma, tumor necrosis factor α, interleukins 2, 4, and 5, but not interleukin 10, are present in recurrent aphthous stomatitis [J].
Buño, IJ ;
Huff, C ;
Weston, WL ;
Cook, DT ;
Brice, SL .
ARCHIVES OF DERMATOLOGY, 1998, 134 (07) :827-831
[3]
DEEM RL, 1991, CLIN EXP IMMUNOL, V83, P79
[4]
CIRCULATING HUMAN PERIPHERAL-BLOOD GRANULOCYTES SYNTHESIZE AND SECRETE TUMOR NECROSIS FACTOR-ALPHA [J].
DUBRAVEC, DB ;
SPRIGGS, DR ;
MANNICK, JA ;
RODRICK, ML .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (17) :6758-6761
[5]
DETECTION OF TUMOR NECROSIS FACTOR FROM LIPOPOLYSACCHARIDE-STIMULATED HUMAN MONONUCLEAR-CELLS BY ENZYME-LINKED IMMUNOSORBENT-ASSAY AND CYTO-TOXICITY BIOASSAY [J].
FOMSGAARD, A ;
WORSAAE, H ;
BENDTZEN, K .
SCANDINAVIAN JOURNAL OF IMMUNOLOGY, 1988, 27 (02) :143-147
[6]
STIMULATION OF THE ADHERENCE OF NEUTROPHILS TO UMBILICAL VEIN ENDOTHELIUM BY HUMAN RECOMBINANT TUMOR-NECROSIS-FACTOR [J].
GAMBLE, JR ;
HARLAN, JM ;
KLEBANOFF, SJ ;
VADAS, MA .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1985, 82 (24) :8667-8671
[7]
CLINICAL-EXPERIENCE WITH THALIDOMIDE IN THE MANAGEMENT OF SEVERE ORAL AND GENITAL ULCERATION IN CONDITIONS SUCH AS BEHCETS-DISEASE - USE OF NEUROPHYSIOLOGICAL STUDIES TO DETECT THALIDOMIDE NEUROPATHY [J].
GARDNERMEDWIN, JMM ;
SMITH, NJ ;
POWELL, RJ .
ANNALS OF THE RHEUMATIC DISEASES, 1994, 53 (12) :828-832
[8]
MAST-CELLS AS A SOURCE OF BOTH PREFORMED AND IMMUNOLOGICALLY INDUCIBLE TNF-ALPHA CACHECTIN [J].
GORDON, JR ;
GALLI, SJ .
NATURE, 1990, 346 (6281) :274-276
[9]
TREATMENT OF APHTHAE WITH THALIDOMIDE [J].
GRINSPAN, D ;
BLANCO, GF ;
AGUERO, S .
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, 1989, 20 (06) :1060-1063
[10]
DISTRIBUTION OF ADHESION RECEPTORS IN RECURRENT ORAL ULCERS [J].
HAYRINENIMMONEN, R ;
MALMSTROM, M ;
NORDSTROM, D ;
SORSA, T ;
KONTTINEN, YT .
JOURNAL OF ORAL PATHOLOGY & MEDICINE, 1992, 21 (05) :199-202