Immunocytochemical localization of cPLA2 in rat and monkey spinal cord

被引：23

作者：

Ong, WY ^{[1
]}

Horrocks, LA

Farooqui, AA

机构：

[1] Natl Univ Singapore, Dept Anat, Singapore 119260, Singapore

[2] Ohio State Univ, Dept Med Biochem, Columbus, OH 43210 USA

来源：

JOURNAL OF MOLECULAR NEUROSCIENCE | 1999年 / 12卷 / 02期

关键词：

phospholipase A(2); arachidonic acid; eicosanoids; spinal cord injury;

D O I：

10.1007/BF02736926

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Rat spinal cord contains a high level of calcium-dependent cytosolic phospholipase A(2) (PLA(2)) activity. A dense immunoreactivity is present in motor neurons from cervical, thoracic, lumbar, and sacral regions of rat spinal cord. Under normal conditions, this enzyme liberates arachidonic acid, a polyunsaturated fatty acid that is a second messenger itself, and a precursor for eicosanoids. However, under pathological conditions during spinal cord injury, intracellular calcium increases so the cytosolic PLA(2) may also be involved in the release and accumulation of arachidonic acid, eicosanoids, and lipid peroxides.

引用

页码：123 / 130

页数：8

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