Chromosomal localization of murine and human oligodendrocyte-specific protein genes

被引：17

作者：

Bronstein, JM

Kozak, CA

Chen, XN

Wu, S

Danciger, M

Korenberg, JR

Farber, DB

机构：

[1] UNIV CALIF LOS ANGELES,SCH MED,DEPT OPHTHALMOL,LOS ANGELES,CA 90024

[2] UNIV CALIF LOS ANGELES,SCH MED,DIV MED GENET,AHMANSON DEPT PEDIAT,CEDARS SINAI RES INST,LOS ANGELES,CA 90024

[3] LOYOLA MARYMOUNT UNIV,LOS ANGELES,CA 90045

[4] NIAID,BETHESDA,MD 20892

来源：

GENOMICS | 1996年 / 34卷 / 02期

关键词：

D O I：

10.1006/geno.1996.0278

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Oligodendrocyte-specific protein (OSP) is a recently described protein present only in myelin of the central nervous system, Several inherited disorders of myelin are caused by mutations in myelin genes but the etiology of many remain unknown, We mapped the location of the mouse OSP gene to the proximal region of chromosome 3 using two sets of multilocus crosses and to human chromosome 3 using somatic cell hybrids, Fine mapping with fluorescence in situ hybridization placed the OSP gene at human chromosome 3q26.2-q26.3. To date, there are no known inherited neurological disorders that localize to these regions. (C) 1996 Academic Press, Inc.

引用

页码：255 / 257

页数：3

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