Insig: a significant integrator of nutrient and hormonal signals

被引：19

作者：

Attie, AD ^{[1
]}

机构：

[1] Univ Wisconsin, Dept Biochem, Madison, WI 53706 USA

来源：

JOURNAL OF CLINICAL INVESTIGATION | 2004年 / 113卷 / 08期

关键词：

D O I：

10.1172/JCI200421450

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Lipogenesis is regulated by sterols and by insulin through the regulated expression and activation of the sterol regulatory element-binding proteins (SREBPs). A new study shows one way in which sterol and insulin regulation can be decoupled (see the related article beginning on page 1168). In transgenic mice overexpressing a protein that regulates SREBP activation, lipogenesis is more sensitive to cholesterol and less sensitive to insulin.

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页码：1112 / 1114

页数：3

相关论文

共 18 条

[1] Overexpression of Insig-1 in the livers of transgenic mice inhibits SREBP processing and reduces insulin-stimulated lipogenesis [J].

Engelking, LJ ;

Kuriyama, H ;

Hammer, RE ;

Horton, JD ;

Brown, MS ;

Goldstein, JL ;

Liang, G .

JOURNAL OF CLINICAL INVESTIGATION, 2004, 113 (08) :1168-1175

[2]

Foretz M, 1999, MOL CELL BIOL, V19, P3760

[3] SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver [J].

Horton, JD ;

Goldstein, JL ;

Brown, MS .

JOURNAL OF CLINICAL INVESTIGATION, 2002, 109 (09) :1125-1131

[4] Regulated cleavage of sterol regulatory element binding proteins requires sequences on both sides of the endoplasmic reticulum membrane [J].

Hua, XX ;

Sakai, J ;

Brown, MS ;

Goldstein, JL .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1996, 271 (17) :10379-10384

[5] Diminished hepatic response to fasting/refeeding and liver X receptor agonists in mice with selective deficiency of sterol regulatory element-binding protein-1c [J].

Liang, GS ;

Yang, J ;

Horton, JD ;

Hammer, RE ;

Goldstein, JL ;

Brown, MS .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2002, 277 (11) :9520-9528

[6] Insulin-regulated hepatic gluconeogenesis through FOXO1-PGC-1α interaction [J].

Puigserver, P ;

Rhee, J ;

Donovan, J ;

Walkey, CJ ;

Yoon, JC ;

Oriente, F ;

Kitamura, Y ;

Altomonte, J ;

Dong, HJ ;

Accili, D ;

Spiegelman, BM .

NATURE, 2003, 423 (6939) :550-555

[7] Regulation of mouse sterol regulatory element-binding protein-1c gene (SREBP-1c) by oxysterol receptors, LXRα and LXRβ [J].

Repa, JJ ;

Liang, GS ;

Ou, JF ;

Bashmakov, Y ;

Lobaccaro, JMA ;

Shimomura, I ;

Shan, B ;

Brown, MS ;

Goldstein, JL ;

Mangelsdorf, DJ .

GENES & DEVELOPMENT, 2000, 14 (22) :2819-2830

[8]

SHIMADA M, 2000, GEOMECH RES SER, V2, P1

[9] Isoform 1c of sterol regulatory element binding protein is less active than isoform 1a in livers of transgenic mice and in cultured cells [J].

Shimano, H ;

Horton, JD ;

Shimomura, I ;

Hammer, RE ;

Brown, MS ;

Goldstein, JL .

JOURNAL OF CLINICAL INVESTIGATION, 1997, 99 (05) :846-854

[10] Insulin selectively increases SREBP-1c mRNA in the livers of rats with streptozotocin-induced diabetes [J].

Shimomura, L ;

Bashmakov, Y ;

Ikemoto, S ;

Horton, JD ;

Brown, MS ;

Goldstein, JL .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (24) :13656-13661