Engineered chimeric antigen receptor-expressing T cells for the treatment of pancreatic ductal adenocarcinoma

被引：14

作者：

Beatty, Gregory L. ^{[1
]}

机构：

[1] Univ Penn, Perelman Sch Med, Abramson Canc Ctr, Dept Med,Div Hematol Oncol, Philadelphia, PA 19104 USA

来源：

ONCOIMMUNOLOGY | 2014年 / 3卷 / 04期

关键词：

adoptive cell therapy; chimeric antigen receptor; T cell; cancer; pancreas; epitope spreading; immunosurveillance; IPILIMUMAB; ANTIBODY; SAFETY;

D O I：

10.4161/onci.28327

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Adoptive cell therapy with chimeric antigen receptor (CAR)-engineered T cells is under investigatation as an approach to restore productive T cell immunosurveillance in pancreatic ductal adenocarcinoma patients. Early findings demonstrate the relative safety of this cell-based therapy and the capacities of CAR-expressing T cells to mount exogenous tumor-specific immunity and induce native antitumoral immune responses.

引用

页数：3

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