Functional CpG methylation system in a social insect

被引：242

作者：

Wang, Ying

Jorda, Mireia

Jones, Peter L.

Maleszka, Ryszard

Ling, Xu

Robertson, Hugh M.

Mizzen, Craig A.

Peinado, Miguel A.

Robinson, Gene E. ^{[1
]}

机构：

[1] Univ Illinois, Dept Entomol, Urbana, IL 61801 USA

[2] Univ Illinois, Inst Genom Biol, Urbana, IL 61801 USA

[3] Univ Illinois, Neurosci Program, Urbana, IL 61801 USA

[4] Univ Illinois, Dept Cell & Dev Biol, Urbana, IL 61801 USA

[5] IDIBELL Canc Res Inst, Lhospitalet De Llobregat 08907, Catalonia, Spain

[6] Australian Natl Univ, Res Sch Biol Sci, Visual Sci & Australian Res Council Ctr Mol Genet, Canberra, ACT, Australia

[7] Univ Illinois, Dept Comp Sci, Urbana, IL 61801 USA

来源：

SCIENCE | 2006年 / 314卷 / 5799期

关键词：

D O I：

10.1126/science.1135213

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

DNA methylation systems are well characterized in vertebrates, but methylation in Drosophila melanogaster and other invertebrates remains controversial. Using the recently sequenced honey bee genome, we present a bioinformatic, molecular, and biochemical characterization of a functional DNA methylation system in an insect. We report on catalytically active orthologs of the vertebrate DNA methyltransferases Dnmt1 and Dnmt3a and b, two isoforms that contain a methyl-DNA binding domain, genomic 5-methyl-deoxycytosine, and CpG-methylated genes. The honey bee provides an opportunity to study the roles of methylation in social contexts.

引用

页码：645 / 647

页数：3

共 19 条

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