Nitroreductase activation of CB1954 - An alternative 'suicide' gene system

被引：9

作者：

Bailey, SM

Hart, IR

机构：

[1] Rayne Institute St Thomas' Hospital,Richard Dimbleby Department of Cancer Research ICRF Laboratory

来源：

GENE THERAPY | 1997年 / 4卷 / 02期

关键词：

D O I：

10.1038/sj.gt.3300400

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

引用

页码：80 / 81

页数：2

共 7 条

[1]

Bailey SM, 1996, GENE THER, V3, P1143

[2] Expression of the bacterial nitroreductase enzyme in mammalian cells renders them selectively sensitive to killing by the prodrug CB1954 [J].

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[3] Selective cell ablation in transgenic mice expressing E-coli nitroreductase [J].

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GENE THERAPY, 1997, 4 (02) :101-110

[4]

Connors TA, 1995, GENE THER, V2, P702

[5] The expression of bacterial nitroreductase in transgenic mice results in specific cell killing by the prodrug CB1954 [J].

Drabek, D ;

Guy, J ;

Craig, R ;

Grosveld, F .

GENE THERAPY, 1997, 4 (02) :93-100

[6] THE BIOACTIVATION OF CB-1954 AND ITS USE AS A PRODRUG IN ANTIBODY-DIRECTED ENZYME PRODRUG THERAPY (ADEPT) [J].

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BOLAND, MP .

CANCER AND METASTASIS REVIEWS, 1993, 12 (02) :195-212

[7] CB-1954 REVISITED .2. TOXICITY AND ANTITUMOR-ACTIVITY [J].

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