Nitric oxide and arterial disease

被引：115

作者：

Barbato, JE ^{[1
]}

Tzeng, E ^{[1
]}

机构：

[1] Univ Pittsburgh, Med Ctr, Dept Surg, Div Vasc Surg, Pittsburgh, PA 15260 USA

来源：

JOURNAL OF VASCULAR SURGERY | 2004年 / 40卷 / 01期

关键词：

D O I：

10.1016/j.jvs.2004.03.043

中图分类号：

R61 [外科手术学];

学科分类号：

摘要：

Nitric oxide (NO) is a molecule that has gained recognition as a crucial modulator of vascular disease. NO has a number of intracellular effects that lead to vasorelaxation, endothelial regeneration, inhibition of leukocyte chemotaxis, and platelet adhesion. Its role in vascular disease has been intensively investigated and further elucidated over the past two decades. It is important in the pathogenesis of many cardiovascular diseases, including atherosclerosis, intimal hyperplasia, and aneurysmal disease. In addition, NO has been used as a therapeutic tool to treat diseases that range from recurrent stenosis to inhibiting thrombotic events. Many commonly used medications have their therapeutic actions through the production of NO. This review highlights the vascular biologic characteristics of NO, its role in the pathogenesis of cardiovascular disease processes, and its potential therapeutic applications.

引用

页码：187 / 193

页数：7

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