Diurnal cortisol amplitude and fronto-limbic activity in response to stressful stimuli

被引：45

作者：

Cunningham-Bussel, Amy C. ^{[1
]}

Root, James C. ^{[1
]}

Butler, Tracy ^{[1
]}

Tuescher, Oliver ^{[1
,7
]}

Pan, Hong ^{[1
,2
]}

Epstein, Jane ^{[1
,2
]}

Weisholtz, Daniel S. ^{[1
]}

Pavony, Michelle ^{[1
]}

Silverman, Michael E. ^{[3
]}

Goldstein, Martin S. ^{[3
]}

Altemus, Margaret ^{[1
]}

Cloitre, Marylene ^{[4
]}

LeDoux, Joseph ^{[5
]}

McEwen, Bruce ^{[6
]}

Stern, Emily ^{[1
,2
]}

Silbersweig, David ^{[1
,2
]}

机构：

[1] Weill Cornell Med Coll, Funct Neuroimaging Lab, Dept Psychiat, New York, NY 10065 USA

[2] Harvard Univ, Sch Med, Dept Psychiat, Brigham & Womens Faulkner Hosp, Cambridge, MA 02138 USA

[3] Mt Sinai Sch Med, New York, NY 10029 USA

[4] NYU, Sch Med, New York, NY 10016 USA

[5] NYU, Ctr Neural Sci, New York, NY 10003 USA

[6] Rockefeller Univ, New York, NY 10021 USA

[7] Univ Freiburg, Dept Neurol, D-7800 Freiburg, Germany

来源：

PSYCHONEUROENDOCRINOLOGY | 2009年 / 34卷 / 05期

关键词：

Amygdala; Medial prefrontal cortex; Hippocampus; Cortisol; Neuroimaging; Stress; CENTRAL-NERVOUS-SYSTEM; GLUCOCORTICOID RECEPTOR; TRANSLATIONAL RESEARCH; WORKING-MEMORY; MESSENGER-RNA; FMRI DATA; HPA-AXIS; DISORDER; BRAIN; CORTICOSTERONE;

D O I：

10.1016/j.psyneuen.2008.11.011

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The development and exacerbation of many psychiatric and neurologic conditions are associated with dysregulation of the hypothalamic pituitary adrenal (HPA) axis as measured by aberrant Levels of cortisol secretion. Here we report on the relationship between the amplitude of diurnal cortisol secretion, measured across 3 typical days in 18 healthy individuals, and blood oxygen Level dependant (BOLD) response in limbic fear/stress circuits, elicited by in-scanner presentation of emotionally negative stimuli, specifically, images of the World Trade Center (WTC) attack. Results indicate that subjects who secrete a greater amplitude of cortisol diurnally demonstrate less brain activation in limbic regions, including the amygdala and hippocampus/parahippocampus, and hypothalamus during exposure to traumatic WTC-related images. Such initial findings can begin to link our understanding, in humans, of the relationship between the diurnal amplitude of a hormone integral to the stress response, and those neuroanatomical regions that are implicated as both modulating and being modulated by that response. (C) 2008 Elsevier Ltd. All rights reserved.

引用

页码：694 / 704

页数：11

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