Ca2+-modulated ONE-GC odorant signal transduction

被引：15

作者：

Duda, Teresa ^{[1
]}

Sharma, Rameshwar K. ^{[1
]}

机构：

[1] Salus Univ, Res Div Biochem & Mol Biol, Unit Regulatory & Mol Biol, Elkins Pk, PA 19027 USA

来源：

FEBS LETTERS | 2009年 / 583卷 / 08期

关键词：

Cyclic GMP; ONE-GC membrane guanylate cyclase; Odorant signal transduction; MEMBRANE GUANYLATE-CYCLASE; NEURONS; SYSTEM; RECEPTOR;

D O I：

10.1016/j.febslet.2009.03.036

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

In a subset of olfactory epithelium the odorant receptor guanylate cyclase, ONE-GC, is a central transduction component of the cyclic GMP signaling pathway. The odorant binds to the extracellular domain and activates its intracellular catalytic domain to generate the odorant second messenger, cyclic GMP. The present study demonstrates that it is a two-step, Ca2+-independent and Ca2+-dependent, sequential process. In step one, the odorant, uroguanylin, binds ONE-GC and primes it for stimulation. In step two, Ca2+-bound neurocalcin d binds to the defined intracellular domain and saturates ONE-GC activity. A prototype model is proposed that depicts this signal transduction process. (C) 2009 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

引用

页码：1327 / 1330

页数：4

共 18 条

[1]

The molecular architecture of odor and pheromone sensing in mammals [J].

Buck, LB .

CELL, 2000, 100 (06) :611-618

[2]

Diuia X, 2007, NEURONAL CALCIUM SEN, P91

[3]

Regulation of photoreceptor membrane guanylyl cyclases by guanylyl cyclase activator proteins [J].

Dizhoor, AM ;

Hurley, JB .

METHODS-A COMPANION TO METHODS IN ENZYMOLOGY, 1999, 19 (04) :521-531

[4]

Calcium-modulated ciliary membrane guanylate cyclase transduction machinery: Constitution and operational principles [J].

Duda, T ;

Fik-Rymarkiewicz, E ;

Venkataraman, V ;

Krishnan, A ;

Sharma, RK .

MOLECULAR AND CELLULAR BIOCHEMISTRY, 2004, 267 (1-2) :107-122

[5]

Ca2+ sensor S100β-modulated sites of membrane guanylate cyclase in thephotoreceptor-bipolar synapse [J].

Duda, T ;

Koch, KW ;

Venkataraman, V ;

Lange, C ;

Beyermann, M ;

Sharma, RK .

EMBO JOURNAL, 2002, 21 (11) :2547-2556

[6]

A novel calcium-regulated membrane guanylate cyclase transduction system in the olfactory neuroepithelium [J].

Duda, T ;

Jankowska, A ;

Venkataraman, V ;

Nagele, RG ;

Sharma, RK .

BIOCHEMISTRY, 2001, 40 (40) :12067-12077

[7]

SITE-DIRECTED MUTATIONAL ANALYSIS OF A MEMBRANE GUANYLATE-CYCLASE CDNA REVEALS THE ATRIAL-NATRIURETIC-FACTOR SIGNALING SITE [J].

DUDA, T ;

GORACZNIAK, RM ;

SHARMA, RK .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1991, 88 (17) :7882-7886

[8]

Duda T., 2006, CALCIUM BIND PROTEIN, V1, P102

[9]

ONE-GC membrane guanylate cyclase, a trimodal odorant signal transducer [J].

Duda, Teresa ;

Sharma, Rameshwar K. .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2008, 367 (02) :440-445

[10]

A subset of olfactory neurons that selectively express cGMP-stimulated phosphodiesterase (PDE2) and guanylyl cyclase-D define a unique olfactory signal transduction pathway [J].

Juilfs, DM ;

Fulle, HJ ;

Zhao, AZ ;

Houslay, MD ;

Garbers, DL ;

Beavo, JA .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1997, 94 (07) :3388-3395

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