Polychlorinated androstanes from the burrowing sponge Cliona nigricans

被引：25

作者：

Fattorusso, E

Taglialatela-Scafati, O

Petrucci, F

Bavestrello, G

Calcinai, B

Cerrano, C

Di Meglio, P

Ianaro, A

机构：

[1] Univ Naples Federico II, Dipartimento Chim Sostanze nat, I-80131 Naples, Italy

[2] Univ Naples Federico II, Dipartimento Farmacol Sperimentale, I-80131 Naples, Italy

[3] Univ Ancona, Dipartimento Sci Mare, I-60131 Ancona, Italy

[4] Univ Genoa, Dipartimento Studio Terr & Risorse, I-16132 Genoa, Italy

来源：

ORGANIC LETTERS | 2004年 / 6卷 / 10期

关键词：

D O I：

10.1021/ol049548r

中图分类号：

O62 [有机化学];

学科分类号：

070303 [有机化学]; 081704 [应用化学];

摘要：

Two new steroidal derivatives, named clionastatins A and B, have been isolated from the burrowing sponge Cliona nigricans. These molecules are tri-and tetrachlorinated androstane derivatives, respectively, and they represent the first polyhalogenated steroids found in a natural organism, either marine or terrestrial, and the first examples of halogenated androstanes in nature. Both clionastatins proved to be potently cytotoxic.

引用

页码：1633 / 1635

页数：3

共 13 条

[1]

Calcinai B., 1999, Memoirs of the Queensland Museum, V44, P77

[2]

3 UNPRECEDENTED CHLORO STEROIDS FROM THE MAUI SPONGE STRONGYLACIDON SP - KIHEISTERONE-C, KIHEISTERONE-D, AND KIHEISTERONE-E [J].