Skin-resident memory CD8+ T cells trigger a state of tissue-wide pathogen alert

被引：425

作者：

Ariotti, Silvia ^{[1
]}

Hogenbirk, Marc A. ^{[2
]}

Dijkgraaf, Feline E. ^{[1
]}

Visser, Lindy L. ^{[1
]}

Hoekstra, Mirjam E. ^{[1
]}

Song, Ji-Ying ^{[3
]}

Jacobs, Heinz ^{[2
]}

Haanen, John B. ^{[1
]}

Schumacher, Ton N. ^{[1
]}

机构：

[1] Netherlands Canc Inst, Div Immunol, NL-1066 CX Amsterdam, Netherlands

[2] Netherlands Canc Inst, Div Biol Stress Response, NL-1066 CX Amsterdam, Netherlands

[3] Netherlands Canc Inst, NL-1066 CX Amsterdam, Netherlands

来源：

SCIENCE | 2014年 / 346卷 / 6205期

基金：

欧洲研究理事会;

关键词：

HERPES-SIMPLEX-VIRUS; ANTIGEN PRESENTATION; LOCAL IMMUNITY; RM CELLS; INFECTION; POPULATION; VACCINE; CD4(+);

D O I：

10.1126/science.1254803

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

070301 [无机化学]; 070403 [天体物理学]; 070507 [自然资源与国土空间规划学]; 090105 [作物生产系统与生态工程];

摘要：

After an infection, pathogen-specific tissue-resident memory T cells (T-RM cells) persist in nonlymphoid tissues to provide rapid control upon reinfection, and vaccination strategies that create T-RM cell pools at sites of pathogen entry are therefore attractive. However, it is not well understood how T-RM cells provide such pathogen protection. Here, we demonstrate that activated T-RM cells in mouse skin profoundly alter the local tissue environment by inducing a number of broadly active antiviral and antibacterial genes. This "pathogen alert" allows skin T-RM cells to protect against an antigenically unrelated virus. These data describe a mechanism by which tissue-resident memory CD8(+) T cells protect previously infected sites that is rapid, amplifies the activation of a small number of cells into an organ-wide response, and has the capacity to control escape variants.

引用

收藏

页码：101 / 105

页数：5

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