Biotransformations of benzoylacetonitrile with the fungus Curvularia lunata:: highly diastereo- and enantioselective synthesis of α-alkyl β-hydroxy nitriles and γ-amino alcohols

被引：28

作者：

Gotor, V ^{[1
]}

Dehli, JR ^{[1
]}

Rebolledo, F ^{[1
]}

机构：

[1] Univ Oviedo, Fac Quim, Dept Quim Organ & Inorgan, E-33071 Oviedo, Spain

来源：

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1 | 2000年 / 03期

关键词：

D O I：

10.1039/a909721j

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Incubation of alcoholic solutions of benzoylacetonitrile, 1, with a suitable aqueous culture of C. lunata results in highly diastereo- and enantioselective reactions leading to alpha-alkyl beta-hydroxy nitriles 3, which are easily reduced to the corresponding gamma-amino alcohols 6.

引用

页码：307 / 309

页数：3

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