Controlled release using mesoporous materials containing gate-like scaffoldings

被引：86

作者：

Aznar, Elena ^{[1
,2
]}

Martinez-Manez, Ramon ^{[1
,2
]}

Sancenon, Felix ^{[1
,2
]}

机构：

[1] Univ Valencia, Inst Reconocimiento Mol & Desarrollo Tecnol, Ctr MixtoUniv Politecn Valencia, E-46003 Valencia, Spain

[2] Univ Politecn Valencia, Dept Quim, Valencia 46022, Spain

来源：

EXPERT OPINION ON DRUG DELIVERY | 2009年 / 6卷 / 06期

关键词：

controlled delivery; gate-like scaffoldings; hybrid materials; mesoporous silica; RESPONSIVE CONTROLLED-RELEASE; SILICA NANOPARTICLES; GUEST MOLECULES; SUPRAMOLECULAR NANOVALVE; DELIVERY-SYSTEM; HYBRID SYSTEMS; CARRIER SYSTEM; DRUG-DELIVERY; PH-DRIVEN; ENSEMBLES;

D O I：

10.1517/17425240902895980

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The use of gated mesoporous silica solids as suitable systems for control led-release protocols is reviewed. These materials are based on mesoporous silica supports that can be prepared with tailor-made pores of around 2 - 10 nm and that show a very large specific surface area (up to 1200 m(2)/g), thus having a large load capacity. The solids can be additionally functionalised in the external surface with gatelike systems that can be opened on command to allow cargo release. Light, redox reactions, pH, temperature, polarity and enzyme-driven protocols are shown. The possible application in drug delivery protocols is discussed.

引用

收藏

页码：643 / 655

页数：13

相关论文

共 40 条

[1] pH-responsive supramolecular nanovalves based on cucurbit[6]uril pseudorotaxanes [J].

Angelos, Sarah ;

Yang, Ying-Wei ;

Patel, Kaushik ;

Stoddart, J. Fraser ;

Zink, Jeffrey I. .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2008, 47 (12) :2222-2226

[2]

Angelos S, 2007, J PHYS CHEM C, V111, P6589, DOI 10.1021/jp0707211

[3] Coordination chemistry and supramolecular chemistry in mesoporous nanospace [J].

Ariga, Katsuhiko ;

Vinu, Ajayan ;

Hill, Jonathan P. ;

Mori, Toshiyuki .

COORDINATION CHEMISTRY REVIEWS, 2007, 251 (21-24) :2562-2591

[4] Photochemical and chemical two-channel control of functional nanogated hybrid architectures [J].

Aznar, Elena ;

Casasus, Rosa ;

Garcia-Acosta, Beatriz ;

Marcos, M. Dolores ;

Martinez-Manez, Ramon .

ADVANCED MATERIALS, 2007, 19 (17) :2228-+

[5] Controlled release of vitamin B2 using mesoporous materials functionalized with amine-bearing gate-like scaffoldings [J].

Bernardos, Andrea ;

Aznar, Elena ;

Coll, Carmen ;

Martinez-Manez, Ramon ;

Manuel Barat, Jose ;

Dolores Marcos, Ma. ;

Sancenon, Felix ;

Benito, Angel ;

Soto, Juan .

JOURNAL OF CONTROLLED RELEASE, 2008, 131 (03) :181-189

[6] Toward the development of ionically controlled nanoscopic molecular gates [J].

Casasús, R ;

Marcos, MD ;

Martínez-Máñez, R ;

Ros-Lis, JV ;

Soto, J ;

Villaescusa, LA ;

Amorós, P ;

Beltrán, D ;

Guillem, C ;

Latorre, J .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2004, 126 (28) :8612-8613

[7] Dual aperture control on pH- and anion-driven supramolecular nanoscopic hybrid gate-like ensembles [J].

Casasus, Rosa ;

Climent, Estela ;

Marcos, Ma. Dolores ;

Martinez-Manez, Ramon ;

Sancenon, Felix ;

Soto, Juan ;

Amoros, Pedro ;

Cano, Joan ;

Ruiz, Eliseo .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2008, 130 (06) :1903-1917

[8] New methods for anion recognition and signaling using nanoscopic gatelike scaffoldings [J].

Casasus, Rosa ;

Aznar, Elena ;

Marcos, M. Dolores ;

Martinez-Manez, Ramon ;

Sancenon, Felix ;

Soto, Juan ;

Amoros, Pedro .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2006, 45 (40) :6661-6664

[9] Nanoscopic hybrid systems with a polarity-controlled gate-like scaffolding for the colorimetric signalling of long-chain carboxylates [J].

Coll, Carmen ;

Casasus, Rosa ;

Aznar, Elena ;

Marcos, M. Dolores ;

Martinez-Manez, Ramon ;

Sancenon, Felix ;

Soto, Juan ;

Amoros, Pedro .

CHEMICAL COMMUNICATIONS, 2007, (19) :1957-1959

[10] Control of molecular transport through stimuli-responsive ordered mesoporous materials [J].

Fu, Q ;

Rao, GVR ;

Ista, LK ;

Wu, Y ;

Andrzejewski, BP ;

Sklar, LA ;

Ward, TL ;

López, GP .

ADVANCED MATERIALS, 2003, 15 (15) :1262-+

← 1 2 3 4 →