Ubiquitin-dependent activation of NF-κB:: K63-linked ubiquitin chains -: A link to cancer?

被引：15

作者：

Chen, ZJJ

Fuchs, SY

机构：

[1] Univ Penn, Sch Vet Med, Dept Anim Biol, Philadelphia, PA 19104 USA

[2] Univ Texas, SW Med Ctr, Dept Mol Biol, Dallas, TX 75230 USA

来源：

CANCER BIOLOGY & THERAPY | 2004年 / 3卷 / 03期

关键词：

NF-kappa B; I kappa B; kinase; ubiquitin; E3; ligase; IKK; nemo; CYLD; cancer;

D O I：

10.4161/cbt.3.3.798

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Recent discoveries of the novel roles of lysine 63-linked polyubiquitin chains in the activation of NF-kappaB transcription factor shed new light on both the mechanistic aspects of this signal transduction pathway and its role in cancer.

引用

页码：286 / 288

页数：3

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