Structure of the human glutamate-L-cysteine ligase catalytic (GLCLC) subunit gene

被引：9

作者：

Gipp, JJ

Mulcahy, RT

机构：

[1] Dept Pharmacol, Madison, WI 53792 USA

[2] Univ Wisconsin, Ctr Comprehens Canc, Madison, WI 53792 USA

来源：

CYTOGENETICS AND CELL GENETICS | 2000年 / 88卷 / 1-2期

关键词：

D O I：

10.1159/000015505

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Glutamate-L-cysteine ligase (GLCL [EC 6.3.2.2], also referred to as gamma-glutamylcysteine synthetase) catalyzes the rate-limiting reaction in the synthesis of the important cellular antioxidant glutathione. GLCL is a heterodimer consisting of a catalytic (GLCLC) and a regulatory (GLCLR) subunit. The structure of the human GLCLC subunit gene, GLCLC, which has been mapped to chromosome 6p12, spans 51.4 kb and consists of 16 exons separated by 15 introns. Copyright (C) 2000 S. Karger AG, Basel.

引用

页码：130 / 132

页数：3

共 11 条

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