Differential sorting and post-secretory targeting of proteins in parasitic invasion

被引:62
作者
Ngô, HM [1 ]
Hoppe, HC [1 ]
Joiner, KA [1 ]
机构
[1] Yale Univ, Sch Med, Dept Internal Med, Infect Dis Sect, New Haven, CT 06520 USA
关键词
D O I
10.1016/S0962-8924(99)01698-0
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Toxoplasma gondii uses a highly coordinated arsenal of three structurally and biochemically distinct secretory granules to invade and develop in a wide range of host cells. Proteins of these secretory granules are sorted to strategic subcellular locations using distinctive sorting signals and ave then triggered differentially for exocytosis, These secreted proteins are subsequently targeted and inserted info membrane domains.
引用
收藏
页码:67 / 72
页数:6
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