Increased expression of lipoprotein lipase in transgenic rabbits does not lead to abnormalities in skeletal and heart muscles

被引：6

作者：

Koike, T

Wang, XF

Unoki, H

Liang, JY

Ichikawa, T

Kitajima, S

Watanabe, T

Fan, JL ^{[1
]}

机构：

[1] Univ Tsukuba, Inst Basic Med Sci, Cardiovasc Dis Lab, Dept Pathol, Tsukuba, Ibaraki 3058575, Japan

[2] Saga Med Sch, Ctr Lab Anim, Saga, Japan

来源：

MUSCLE & NERVE | 2002年 / 26卷 / 06期

关键词：

free fatty acids; lipids; lipoprotein lipase; lipoprotein metabolism; myopathies; transgenic;

D O I：

10.1002/mus.10282

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Lipoprotein lipase (LPL) plays an important role in plasma lipoprotein metabolism and the uptake of free fatty acid in muscle. Previous studies using transgenic mice showed that increased LPL leads to myopathies, but these results were controversial. To examine this hypothesis, we studied LPL transgenic rabbits, and our results refute the suggested role of LPL in the pathogenesis of myopathies. (C) 2002 Wiley Periodicals, Inc.

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页码：823 / 827

页数：5

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