Blood-brain barrier choline transport in the senescent rat

被引:17
作者
Allen, DD
Smith, QR
机构
[1] Texas Tech Univ, Hlth Sci Ctr, Sch Pharm, Dept Pharmaceut Sci, Amarillo, TX 79106 USA
[2] NIA, Neurosci Lab, NIH, Bethesda, MD 20892 USA
关键词
choline; blood-brain barrier; transporter; aging; acetylcholine; hemicholinium-3; cerebrovascular;
D O I
10.1016/S0304-3940(99)00869-1
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Choline is an important membrane phospholipid constituent and a neurotransmitter precursor that is minimally synthesized in brain. The long-term maintenance of brain choline concentration is dependent on uptake from plasma, which occurs via saturable transporter at the blood-brain barrier. Previous studies have suggested that brain choline uptake declined with age. To reevaluate this, brain choline uptake in 3, 12, 24, and 28-month-old Fischer-344 rats was evaluated using the in situ brain perfusion technique. Minimal differences were found with uptake parameters differing by similar to 10% between aged and adult rats for tracer levels while similar trends were observed at higher choline concentrations. Further, estimated V-max and K-m values differed by <30% between the groups. The results suggest that blood-brain barrier choline uptake changes minimally with aging in the rat. (C) 1999 Elsevier Science Ireland Ltd. All rights reserved.
引用
收藏
页码:198 / 202
页数:5
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