Statins Improve Survival in Patients With Cardioembolic Stroke

被引：36

作者：

Choi, Jeong-Yoon ^{[1
]}

Seo, Woo-Keun ^{[2
]}

Kang, Sung Hoon ^{[2
]}

Jung, Jin-Man ^{[1
]}

Cho, Kyung-Hee ^{[3
]}

Yu, Sungwook ^{[3
]}

Oh, Kyungmi ^{[2
]}

机构：

[1] Korea Univ, Ansan Hosp, Dept Neurol, Ansan, GyeongGi Provin, South Korea

[2] Korea Univ, Guro Hosp, Dept Neurol, Seoul 152703, South Korea

[3] Korea Univ, Anam Hosp, Dept Neurol, Seoul 152703, South Korea

来源：

STROKE | 2014年 / 45卷 / 06期

关键词：

embolism; mortality; outcome; recurrence; statin; stroke; HEALTH-CARE PROFESSIONALS; TRANSIENT ISCHEMIC ATTACK; ATRIAL-FIBRILLATION; AORTIC PLAQUE; RISK-FACTORS; THERAPY; ASSOCIATION; GUIDELINES;

D O I：

10.1161/STROKEAHA.114.005518

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Background and Purpose-The objective of this study was to investigate the potential benefits of statin therapy on mortality and stroke recurrence after cardioembolic stroke. Methods-In this retrospective observational study, we analyzed data from 535 patients with first-ever cardioembolic stroke. Patients were classified into nonstatin, low-potency statin, and high-potency statin groups. The primary outcomes were time to mortality and time to recurrent stroke. Results-The mean duration of follow-up was 22.2 months. The cumulative mortality rate was 7% at the end of the first year and 10% at the end of the third year. Statin therapy was independently associated with reduced mortality (hazard ratio, 0.237; 95% confidence interval, 0.080-0.703 for nonstatin versus low-potency statin; hazard ratio, 0.158; 95% confidence interval, 0.037-0.686 for nonstatin versus high-potency statin). Statin treatment did not affect the incidence of recurrent stroke in patients with cardioembolic stroke. Conclusions-Statin therapy could be associated with reduced mortality in patients with cardioembolic stroke.

引用

页码：1849 / +

页数：15

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