Serotonin metabolite excretion after postmenopausal estradiol therapy

被引：38

作者：

Lippert, TH ^{[1
]}

Filshie, M ^{[1
]}

Muck, AO ^{[1
]}

Seeger, H ^{[1
]}

Zwirner, M ^{[1
]}

机构：

[1] QUEENS MED CTR, DEPT OBSTET & GYNECOL, NOTTINGHAM NG7 2UH, ENGLAND

来源：

MATURITAS | 1996年 / 24卷 / 1-2期

关键词：

estradiol; 5-hydroxyindole acetic acid; postmenopause;

D O I：

10.1016/0378-5122(95)00998-1

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

Serotonin, known for its beneficial action on mood and well-being, is also involved in cardiovascular functions. Thus the current work was undertaken to study the effect of hormone replacement therapy on serotonin turnover in postmenopausal women. Eighteen women received estradiol transdermally and 17 women estradiol valerate orally for 4 weeks. The serotonin metabolite 5-hydroxyindole acetic acid (5-HIAA) was determined in the urine before, and after 2 and 4 weeks' estradiol treatment. With both administration routes estradiol produced a significant increase in urinary 5-HIAA excretion, greatest with transdermal estradiol after 28 days of treatment. The enhancement of serotonin turnover may contribute not only to an improvement of mood and well-being but also to a cardioprotective effect of estradiol observed after hormone substitution in postmenopausal women.

引用

页码：37 / 41

页数：5

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