Induction of de novo subcortical actin filament assembly by Treponema denticola major outer sheath protein

被引：25

作者：

Amin, M

Ho, ACS

Lin, JY

da Silva, APB

Glogauer, M

Ellen, RP

机构：

[1] Univ Toronto, Fac Dent, CIHR Grp Matrix Dynam, Toronto, ON M5G 1G6, Canada

[2] Univ Toronto, Dent Res Inst, Toronto, ON M5G 1G6, Canada

来源：

INFECTION AND IMMUNITY | 2004年 / 72卷 / 06期

关键词：

D O I：

10.1128/IAI.72.6.3650-3654.2004

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Treponema denticola and its major outer sheath protein (Msp) induce actin reorganization in fibroblasts. We adapted a barbed-end labeling/imaging assay to monitor Msp-induced subcortical actin filament assembly in neutrophils and fibroblasts. Msp, at an actin-reorganizing concentration, inhibited migration of these dissimilar cell types, whose cytoskeletal functions in locomotion and phagocytosis are crucial for immunity and healing of peripheral infections.

引用

收藏

页码：3650 / 3654

页数：5

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