Optical Doppler tomography for noninvasive imaging of in vivo blood flow

被引：6

作者：

Chen, ZP

Milner, TE

Srinivas, S

Lindmo, T

Dave, D

Nelson, JS

机构：

来源：

COHERENCE DOMAIN OPTICAL METHODS IN BIOMEDICAL SCIENCE AND CLINICAL APPLICATIONS, PROCEEDINGS OF | 1997年 / 2981卷

关键词：

optical Doppler tomography; optical coherence tomography; blood flow imaging; laser Doppler velocimetry;

D O I：

10.1117/12.274308

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

We report the development of an optical technique for noninvasive in vivo imaging of tissue structure and blood flow dynamics with high spatial resolution (2-15 mu m) in biological systems. The technique is based on coherence optical Doppler tomography (ODT), which combines Doppler velocimetry with optical coherence tomography to measure blood now velocity at discrete spatial locations. The exceptionally high resolution of ODT allows noninvasive in vivo imaging of both blood microcirculation and tissue structures surrounding the vessel, which has significance for biomedical research and clinical applications. Tomographic velocity imaging of in viva blood flow in a rat mesentery is demonstrated.

引用

页码：112 / 118

页数：7