Innate immune recognition of microbes through Nod1 and Nod2: implications for disease

被引：63

作者：

Carneiro, LAM

Travassos, LH

Philpott, DJ

机构：

[1] Inst Pasteur, Grp Immun & Signalisat, F-75724 Paris 15, France

[2] Univ Estado Rio de Janeiro, Fac Ciencias Med, BR-20550030 Rio De Janeiro, Brazil

来源：

MICROBES AND INFECTION | 2004年 / 6卷 / 06期

关键词：

innate immunity; Nod1; Nod2; toll-like receptors; peptidoglycan;

D O I：

10.1016/j.micinf.2004.01.012

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Nod1 and Nod2 are cytosolic proteins involved in intracellular recognition of microbes and their products. Recently, it was shown that these proteins recognize different moieties of bacterial peptidoglycan (PGN) mediating non-specific pathogen resistance and possibly generating signals for the adaptive immune response. Moreover, mutations in the gene encoding Nod2 are associated with increased susceptibility to chronic inflammatory disorders. (C) 2004 Elsevier SAS. All rights reserved.

引用

收藏

页码：609 / 616

页数：8

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