Progestins and androgens increase expression of Spot 14 in T47-D breast tumor cells

被引：12

作者：

Heemers, H ^{[1
]}

Vanderhoydonc, F ^{[1
]}

Heyns, W ^{[1
]}

Verhoeven, G ^{[1
]}

Swinnen, JV ^{[1
]}

机构：

[1] Catholic Univ Louvain, Onderwijs Navorsing Gasthuisberg, Fac Med, Lab Expt Med & Endocrinol, B-3000 Louvain, Belgium

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2000年 / 269卷 / 01期

关键词：

breast cancer; steroid receptors; lipids; gene expression;

D O I：

10.1006/bbrc.2000.2262

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Enhanced expression of fatty acid synthase and other lipogenic enzymes has been observed in a subset of breast cancers with poor prognosis. This phenomenon has been related to amplification of a gene on chromosome region 11q13 encoding Spot 14, a putative regulator of lipogenic enzyme expression. In this paper we demonstrate that the induction of lipogenesis by progestins and androgens in the breast cancer cell line T47-D is accompanied by a marked increase in the expression of Spot 14. These data corroborate the correlation between Spot 14 expression and increased lipogenesis. Moreover they show that apart from gene amplification there is another steroid-regulated pathway that may enhance Spot 14 expression and lipogenesis in tumor cells. (C) 2000 Academic Press.

引用

页码：209 / 212

页数：4

共 28 条

[1] Fatty acid synthase (FAS) predictive strength in poorly differentiated early breast carcinomas [J].